A toxicological risk assessment for a substance is always based on the same steps:
  • Search for toxicological data (typically animal or human studies)
  • If needed: Design of appropriate studies to create data for the relevant toxicological endpoint(s) like acute and repeated dose toxicity, sensitisation, irritation etc.
  • Evaluation of the data
  • Stating of the most relevant toxicological endpoint
  • Derivation of a threshold (ADI, TDI, PDE, RfD etc), which is defined as a substance specific dose, that is unlikely to cause an adverse effect, if an individual (human) is exposed at or below this dose every day for a lifetime
  • Exposure calculation by using measured data or results from simulation calculations
  • Comparison of the calculated/measured exposure data with the derived threshold
  • Assessment of the risk for the exposed target group.
The target groups may differ widely and depends on the source of the substance to be evaluated and on the product, which is concerned.
Consequently our work can have different scopes, which are to be presented on the following pages.

Tox Expert GmbH
An der Feldscheide 1
37083 Göttingen